Gene information
Official symbol CYP2C8
Official full name cytochrome P450 family 2 subfamily C member 8
Gene type protein-coding gene
Chromosome10q23.33
Alias symbolCPC8
Gene familyCytochrome P450 family 2
Resources
Entrez Gene 1558
HGNC HGNC:2622
Ensembl ENSG00000138115
Vega OTTHUMG00000018804
UCSC uc001kkb.4
GO terms: 52 records
GO Description Category LogP Number of genes Detail
GO:0001523 retinoid metabolic process GO Biological Processes -3.75216665 12 More
GO:0001676 long-chain fatty acid metabolic process GO Biological Processes -13.6883394 17 More
GO:0004497 monooxygenase activity GO Molecular Functions -11.8172125 15 More
GO:0005506 iron ion binding GO Molecular Functions -10.4063739 16 More
GO:0006066 alcohol metabolic process GO Biological Processes -16.7128396 29 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006633 fatty acid biosynthetic process GO Biological Processes -12.0711739 16 More
GO:0006690 icosanoid metabolic process GO Biological Processes -21.0788451 23 More
GO:0006720 isoprenoid metabolic process GO Biological Processes -5.01065294 9 More
GO:0006721 terpenoid metabolic process GO Biological Processes -4.89883771 15 More
GO:0006805 xenobiotic metabolic process GO Biological Processes -8.19045514 12 More
GO:0008202 steroid metabolic process GO Biological Processes -19.3229835 29 More
GO:0008210 estrogen metabolic process GO Biological Processes -4.13864672 5 More
GO:0008391 arachidonic acid monooxygenase activity GO Molecular Functions -6.90547690 6 More
GO:0008392 arachidonic acid epoxygenase activity GO Molecular Functions -7.53000143 6 More
GO:0008395 steroid hydroxylase activity GO Molecular Functions -9.29772341 9 More
GO:0008610 lipid biosynthetic process GO Biological Processes -6.38047816 23 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0016101 diterpenoid metabolic process GO Biological Processes -3.60396371 12 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO Molecular Functions -11.3284001 18 More
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO Molecular Functions -13.5752504 12 More
GO:0016725 oxidoreductase activity, acting on CH or CH2 groups GO Molecular Functions -3.88065666 3 More
GO:0019369 arachidonic acid metabolic process GO Biological Processes -15.7454969 15 More
GO:0019373 epoxygenase P450 pathway GO Biological Processes -8.85891522 7 More
GO:0020037 heme binding GO Molecular Functions -15.4577568 20 More
GO:0030258 lipid modification GO Biological Processes -3.55367288 9 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0033559 unsaturated fatty acid metabolic process GO Biological Processes -16.8056258 19 More
GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor GO Molecular Functions -5.18367662 3 More
GO:0034308 primary alcohol metabolic process GO Biological Processes -3.85295720 7 More
GO:0034875 caffeine oxidase activity GO Molecular Functions -5.18367662 3 More
GO:0042178 xenobiotic catabolic process GO Biological Processes -7.90595898 7 More
GO:0042445 hormone metabolic process GO Biological Processes -9.53279610 17 More
GO:0042572 retinol metabolic process GO Biological Processes -3.60984508 9 More
GO:0042573 retinoic acid metabolic process GO Biological Processes -2.19704927 3 More
GO:0042759 long-chain fatty acid biosynthetic process GO Biological Processes -7.41220618 7 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0046456 icosanoid biosynthetic process GO Biological Processes -13.7551761 13 More
GO:0046906 tetrapyrrole binding GO Molecular Functions -14.8570803 20 More
GO:0070330 aromatase activity GO Molecular Functions -7.90595898 7 More
GO:0070988 demethylation GO Biological Processes -3.87651549 6 More
GO:0070989 oxidative demethylation GO Biological Processes -7.19780504 6 More
GO:0071466 cellular response to xenobiotic stimulus GO Biological Processes -9.33788411 28 More
GO:0072330 monocarboxylic acid biosynthetic process GO Biological Processes -12.0346130 18 More
GO:0097267 omega-hydroxylase P450 pathway GO Biological Processes -9.26986898 6 More
GO:0101020 estrogen 16-alpha-hydroxylase activity GO Molecular Functions -4.05291246 3 More
GO:0120254 olefinic compound metabolic process GO Biological Processes -12.8805599 18 More
GO:1901615 organic hydroxy compound metabolic process GO Biological Processes -22.7091625 41 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa00590 Arachidonic acid metabolism KEGG Pathway -11.1782370 12 More
hsa00591 Linoleic acid metabolism KEGG Pathway -5.99805120 6 More
hsa00830 Retinol metabolism KEGG Pathway -2.89013962 5 More
hsa00982 Drug metabolism - cytochrome P450 KEGG Pathway -7.86918833 10 More
hsa04726 Serotonergic synapse KEGG Pathway -8.91693578 13 More
hsa05204 Chemical carcinogenesis - DNA adducts KEGG Pathway -6.89688307 9 More
Drug-Gene interaction
view
Related drugs: 25 records
Drug name Interaction type Source PMID View
amodiaquine PharmGKB 17361129219984722320418318855526 view
atorvastatin PharmGKB view
carbamazepine PharmGKB 21738081 view
cerivastatin PharmGKB 1536588011844864 view
chembl530733 DTC view
clopidogrel PharmGKB 24971633 view
flibanserin PharmGKB view
fluorouracil PharmGKB view
fluvastatin PharmGKB view
gemcitabine PharmGKB 31616045 view
ibuprofen PharmGKB 26122864182167201528978925502615305622141869483119480553 view
lovastatin PharmGKB view
montelukast PharmGKB 28940478 view
pamidronic acid PharmGKB 18594024 view
pazopanib PharmGKB 25504632 view
repaglinide PharmGKB 1792385115961978145345251838887721270106 view
rifampin NCI 15771232 view
rosiglitazone PharmGKB 171782662342638227271184 view
rucaparib PharmGKB view
simeprevir PharmGKB view
simvastatin PharmGKB 25504632 view
sorafenib PharmGKB 28362716 view
tacrolimus PharmGKB 187693652831608723426640 view
trimethoprim NCI 15606443 view
zoledronic acid PharmGKB 18594024 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
NG_007972.1:g.37394C>T genomics myocardial infarction[diagnosis] myocardial infarction Rodenburg EM et al. Pharmacogenet Genomics. 2010
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